DIABETES
VOL. 45, SUPPLEMENT 3, JULY 1996
Coronary Heart Disease and NIDDM in Japanese-Americans
Wilfred Y. Fujimoto, Richard W. Bergstrom, Edward J. Boyko, Donna L. Leonetti, Laura L. Newell-Morris, and Patricia W. Wahl
Glucose intolerance is associated with increased risk of
coronary heart disease (CHD) in Japanese-Americans, especially in
men. Intra-abdominal fat, assessed by computed tomography, is
increased in those with both NIDDM and CHD. Increased
intra-abdominal fat (visceral adiposity) with CHD is independent
of NIDDM or impaired glucose tolerance. The association between
NIDDM and CHD may be explained by the association of each of
these conditions with visceral adiposity. However,
hyperinsulinemia is associated with CHD only in the presence of
diabetes, whereas triglyceride levels are elevated with CHD
independent of glucose tolerance category. These findings suggest
that factors other than insulin levels, such as lipids, may
mediate the relationship between visceral adiposity and CHD.
Moreover, these relationships are influenced by gender. Diabetes
45 (Suppl. 3):S17-S18, 1996
Copyright © 1996 American Diabetes Association
Last updated: 7/15/96
For ADA Related Issues contact CustomerService@diabetes.org
For Technical Issues contact webmaster@diabetes.org