DIABETES, VOLUME 45, SUPPLEMENT 1, JANUARY 1996, PAGES S15-S19

Kallikreins and Kinins

Molecular Characteristics and Cellular and Tissue Responses

Harry S. Margolius

Kallikrein-kininogen-kinin systems are now topics of widespread interest. The long-standing appreciation of their diverse pharmacological properties and biochemical characteristics is being supplemented by modern definitions of their cellular receptors' signal-transduction mechanisms and physiological and pathological roles. The assignment of important homeostatic responsibilities for chins, including those in autocrine and paracrine signalng for skeletal and cardiac muscle energy metabolism, is now subject to definitive experimental evaluation via the availability of better kallikrein inhibitors, specific kinin receptor antagonists, and techniques of genetic manipulation. Diabetes 45 (Suppl. 1):S14-Sl9, 1996

Copyright © 1996 American Diabetes Association

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